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AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.
Soutar, Marc P M; Kempthorne, Liam; Miyakawa, Shuichi; Annuario, Emily; Melandri, Daniela; Harley, Jasmine; O'Sullivan, Gregory A; Wray, Selina; Hancock, David C; Cookson, Mark R; Downward, Julian; Carlton, Mark; Plun-Favreau, Hélène.
Afiliação
  • Soutar MPM; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. m.soutar@ucl.ac.uk.
  • Kempthorne L; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Miyakawa S; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
  • Annuario E; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Melandri D; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Harley J; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • O'Sullivan GA; CereVance Ltd. 418 Science Park, Milton Rd, Cambridge, CB4 0PZ, UK.
  • Wray S; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Hancock DC; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Cookson MR; Laboratory of Neurogenetics, NIH, Building 35, Room 1A116, 35 Convent Drive, Bethesda, MD, 20814, USA.
  • Downward J; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Carlton M; CereVance Ltd. 418 Science Park, Milton Rd, Cambridge, CB4 0PZ, UK.
  • Plun-Favreau H; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. h.plun-favreau@ucl.ac.uk.
Sci Rep ; 8(1): 8855, 2018 06 11.
Article em En | MEDLINE | ID: mdl-29891871
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Mitofagia / Mitocôndrias / Neurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Mitofagia / Mitocôndrias / Neurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido