Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study.
Head Neck Pathol
; 13(2): 208-214, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-29931661
ABSTRACT
Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Extraoral cases as well as cases with insufficient patient information were excluded. A total of 340 out of 164,578 submitted specimens in a 22 year period (0.2%) were included with a mean age of 43.3 years (range 6-89), and 44% male and 56% female. The most commonly affected locations were tongue (37.5%), palate (22%), lip (19%), and gingiva (14%). The microscopic diagnoses rendered, in descending order of frequency were neurofibromas (NFs) 123 (36%), granular cell tumor (GCT) 108 (32%), schwannomas 61 (17%), palisaded encapsulated neuromas 39 (11%), benign neural lesion not otherwise specified 8 (2%), and mucosal neuroma c/w multiple endocrine neoplasia type 2B (MEN 2B) 1 (< 0.5%). Six cases of NF reported a history of neurofibromatosis Type 1 (NF 1). Four cases showed multifocal lesions. Immunohistochemical staining was performed on equivocal cases (25% of the lesions) and all were confirmed by their S-100 positivity. Intraoral neural neoplasms, though uncommon should be in the differential diagnosis of oral soft tissue entities and specific consideration to syndromal linkage is paramount as this may impact patient management.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Neoplasias de Tecido Nervoso
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
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Aged
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Aged80
/
Child
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Head Neck Pathol
Assunto da revista:
NEOPLASIAS
/
PATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos