Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken.
Environ Toxicol Chem
; 37(10): 2513-2522, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-29947098
ABSTRACT
Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken (Gallus domesticus). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the domestic chicken over a range of doses. Chicken eggs were injected with the PCB mixture with a profile similar to that found in avian eggs collected on the upper Hudson River, New York, USA, at doses that spanned 0 to 98 µg/g egg. Eggs were hatched in the laboratory to ascertain hatching success. In the domestic chicken, the median lethal dose was 0.3 µg/g. These data demonstrate adverse effects of an environmentally relevant PCB mixture and provide the basis for further work using in vitro and other models to characterize the potential risk to avian populations. Environ Toxicol Chem 2018;372513-2522. © 2018 SETAC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bifenilos Policlorados
/
Poluentes Ambientais
/
Animais Domésticos
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Environ Toxicol Chem
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos