Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.

Choi, Seong Won; Gu, Yuexi; Peters, Ryan Scott; Salgame, Padmini; Ellner, Jerrold J; Timmins, Graham S; Deretic, Vojo

Choi, Seong Won; Gu, Yuexi; Peters, Ryan Scott; Salgame, Padmini; Ellner, Jerrold J; Timmins, Graham S; Deretic, Vojo.

Afiliação

Choi SW; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Gu Y; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Peters RS; Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Salgame P; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Ellner JJ; Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Timmins GS; Division of Infectious Disease, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Deretic V; Division of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.

Antimicrob Agents Chemother ; 62(9)2018 09.

Article em En | MEDLINE | ID: mdl-30012752

ABSTRACT

ABSTRACT

Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy in vitro and in vivo and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.

Assuntos

Ambroxol/farmacologia; Antituberculosos/farmacologia; Autofagia/efeitos dos fármacos; Mycobacterium tuberculosis/efeitos dos fármacos; Rifampina/farmacologia; Tuberculose/tratamento farmacológico; Animais; Macrófagos/efeitos dos fármacos; Macrófagos/microbiologia; Camundongos; Camundongos Endogâmicos C57BL; Tuberculose/microbiologia

Palavras-chave

Mycobacterium tuberculosis; autophagy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rifampina / Autofagia / Tuberculose / Ambroxol / Mycobacterium tuberculosis / Antituberculosos Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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