Safety of Etanercept in the treatment of rheumatic disease patients with Hepatitis C virus infection.
Acta Reumatol Port
; 43(2): 159-160, 2018.
Article
em En
| MEDLINE
| ID: mdl-30091962
ABSTRACT
Hepatitis C virus (HCV) infection is a major public health problem. Because Tumour Necrosis Factor (TNF) seems to have an important role in immune response to HCV infection, suppression by TNFi (TNF inhibitors) may pose a potential worsening of chronic HCV infection. We report our experience with 3 cases of patients with chronic HCV infection and advanced liver disease, with different Rheumatic diseases, treated with a TNFi, etanercept (ETN), for a period ranging from 4 months to 4 years without hepatitis C treatment and, in two of them, concomitant therapy with direct-acting antiviral agents (DAA) and afterwards. Although increasing number of clinical reports support the short-term safety and efficacy of TNFi in patients with HCV, some uncertainties remain regarding long-term. These cases suggests that the risk of HCV reactivation related to TNFi remains low even without concomitant antiviral therapy. Nevertheless, a strict collaboration between rheumatologists and gastroenterologists/hepatologists. Our results also showed a good tolerance and efficacy when used concomitantly the new direct-acting antivirals drugs with ETN.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Reumáticas
/
Antirreumáticos
/
Etanercepte
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Reumatol Port
Ano de publicação:
2018
Tipo de documento:
Article