Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome.
Cell Physiol Biochem
; 48(5): 1882-1893, 2018.
Article
em En
| MEDLINE
| ID: mdl-30092590
ABSTRACT
BACKGROUND/AIMS:
We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC).METHODS:
The study involved 40 patients with stage IV HCC who were divided equally into two groups 1) simple IRE; and 2) IRE plus allogenic NK cells (IRE-NK); we mainly assessed the overall survival (OS).RESULTS:
The effect of the IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, it also decreased alpha-fetoprotein expression and showed significantly good clinical effectiveness. At the median 7.6-month follow-up (range, 3.8-12.1 months), median OS was higher in the IRE-NK group (10.1 months) than in the IRE group (8.9 months, P = 0.0078).CONCLUSION:
IRE combined with allogeneic NK cell immunotherapy significantly increases the median OS of patients with stage IV HCC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cell Physiol Biochem
Assunto da revista:
BIOQUIMICA
/
FARMACOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China