A comparison of the effects of selective and non-selective mineralocorticoid antagonism on glucose homeostasis of heart failure patients with glucose intolerance or type II diabetes: A randomized controlled double-blind trial.
Am Heart J
; 204: 190-195, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30097164
ABSTRACT
Mineralocorticoid receptor antagonists (MRAs) decrease morbidity and mortality in patients with heart failure (HF). However, spironolactone, a non-selective MRA, has been shown to exert a harmful effect on glucose homeostasis. The objective of this multicenter, randomized, controlled, double-blind trial was to compare the effects of spironolactone to those of the selective MRA eplerenone on glucose homeostasis among 62 HF patients with glucose intolerance or type II diabetes. Trial registration numberNCT01586442.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
1_doencas_nao_transmissiveis
/
2_muertes_prematuras_enfermedades_notrasmisibles
/
6_cardiovascular_diseases
/
6_diabetes
/
6_endocrine_disorders
/
6_other_circulatory_diseases
/
6_sense_organ_diseases
Assunto principal:
Espironolactona
/
Glicemia
/
Intolerância à Glucose
/
Diabetes Mellitus Tipo 2
/
Antagonistas de Receptores de Mineralocorticoides
/
Eplerenona
/
Insuficiência Cardíaca
/
Homeostase
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am Heart J
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá
