Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.

Sandstedt, Mikael; Rotter Sopasakis, Victoria; Lundqvist, Annika; Vukusic, Kristina; Oldfors, Anders; Dellgren, Göran; Sandstedt, Joakim; Hultén, Lillemor Mattsson

Sandstedt, Mikael; Rotter Sopasakis, Victoria; Lundqvist, Annika; Vukusic, Kristina; Oldfors, Anders; Dellgren, Göran; Sandstedt, Joakim; Hultén, Lillemor Mattsson.

Afiliação

Sandstedt M; Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Rotter Sopasakis V; Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lundqvist A; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Vukusic K; Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Oldfors A; Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Dellgren G; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital and Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sandstedt J; Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hultén LM; Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

PLoS One ; 13(8): e0202693, 2018.

Article em En | MEDLINE | ID: mdl-30138423

Assuntos

Araquidonato 15-Lipoxigenase/genética; Araquidonato 15-Lipoxigenase/metabolismo; Insuficiência Cardíaca/patologia; Miócitos Cardíacos/citologia; Adulto; Idoso; Ácido Araquidônico/metabolismo; Biópsia; Cálcio/metabolismo; Hipóxia Celular; Células Cultivadas; Feminino; Fibroblastos; Insuficiência Cardíaca/genética; Insuficiência Cardíaca/metabolismo; Insuficiência Cardíaca/terapia; Frequência Cardíaca; Transplante de Coração; Humanos; Ácidos Hidroxieicosatetraenoicos/metabolismo; Células-Tronco Pluripotentes Induzidas/citologia; Células-Tronco Pluripotentes Induzidas/metabolismo; Masculino; Pessoa de Meia-Idade; Miócitos Cardíacos/metabolismo; Comunicação Parácrina; Transdução de Sinais; Doadores de Tecidos; Regulação para Cima

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Assunto principal: Araquidonato 15-Lipoxigenase / Miócitos Cardíacos / Insuficiência Cardíaca Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suécia

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