Targeting Breast Cancer Stem Cells: A Methodological Perspective.
Curr Stem Cell Res Ther
; 14(5): 389-397, 2019.
Article
em En
| MEDLINE
| ID: mdl-30147014
ABSTRACT
Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Neoplasias da Mama
/
Antineoplásicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Curr Stem Cell Res Ther
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
México