Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology.
Endocr Rev
; 40(1): 66-95, 2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30169559
ABSTRACT
A plethora of physiological processes show stable and synchronized daily oscillations that are either driven or modulated by biological clocks. A circadian pacemaker located in the suprachiasmatic nucleus of the ventral hypothalamus coordinates 24-hour oscillations of central and peripheral physiology with the environment. The circadian clockwork involved in driving rhythmic physiology is composed of various clock genes that are interlocked via a complex feedback loop to generate precise yet plastic oscillations of â¼24 hours. This review focuses on the specific role of the core clockwork gene Period1 and its paralogs on intra-oscillator and extra-oscillator functions, including, but not limited to, hippocampus-dependent processes, cardiovascular function, appetite control, as well as glucose and lipid homeostasis. Alterations in Period gene function have been implicated in a wide range of physical and mental disorders. At the same time, a variety of conditions including metabolic disorders also impact clock gene expression, resulting in circadian disruptions, which in turn often exacerbates the disease state.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Ritmo Circadiano
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Proteínas Circadianas Period
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Relógios Circadianos
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Homeostase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Endocr Rev
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália