The effects of cardiomyopathy-associated mutations in the head-to-tail overlap junction of &#945;-tropomyosin on its properties and interaction with actin.

Matyushenko, Alexander M; Koubassova, Natalia A; Shchepkin, Daniil V; Kopylova, Galina V; Nabiev, Salavat R; Nikitina, Larisa V; Bershitsky, Sergey Y; Levitsky, Dmitrii I; Tsaturyan, Andrey K

The effects of cardiomyopathy-associated mutations in the head-to-tail overlap junction of α-tropomyosin on its properties and interaction with actin.

Matyushenko, Alexander M; Koubassova, Natalia A; Shchepkin, Daniil V; Kopylova, Galina V; Nabiev, Salavat R; Nikitina, Larisa V; Bershitsky, Sergey Y; Levitsky, Dmitrii I; Tsaturyan, Andrey K.

Afiliação

Matyushenko AM; Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, 33 Leninsky prosp., Moscow 119071, Russia; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Koubassova NA; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia; Institute of Mechanics, Moscow State University, 1 Mitchurinsky prosp., Moscow 119192, Russia.
Shchepkin DV; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Kopylova GV; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Nabiev SR; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Nikitina LV; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Bershitsky SY; Institute of Immunology and Physiology, Russian Academy of Sciences, 91 Pervomayskaya ul., Yekaterinburg 620049, Russia.
Levitsky DI; Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, 33 Leninsky prosp., Moscow 119071, Russia; Belozersky Institute of Physico-Chemical Biology, Moscow State University, 1 Leninskiye Gory bld. 40, Moscow 119234, Russia.
Tsaturyan AK; Institute of Mechanics, Moscow State University, 1 Mitchurinsky prosp., Moscow 119192, Russia. Electronic address: tsat@imec.msu.ru.

Int J Biol Macromol ; 125: 1266-1274, 2019 Mar 15.

Article em En | MEDLINE | ID: mdl-30240712

Assuntos

Actinas/metabolismo; Cardiomiopatias/genética; Cardiomiopatias/metabolismo; Mutação; Tropomiosina/genética; Tropomiosina/metabolismo; Acetilação; Actinas/química; Animais; Humanos; Conformação Molecular; Simulação de Dinâmica Molecular; Miocárdio; Ligação Proteica; Domínios Proteicos; Estabilidade Proteica; Desdobramento de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Análise Espectral; Tropomiosina/química; Viscosidade

Palavras-chave

Cardiac muscle; Cardiomyopathy; Mutation; Overlap junction; Tropomyosin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tropomiosina / Actinas / Mutação / Cardiomiopatias Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa

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