PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.

Yano, Hiroyuki; Sakai, Mashito; Matsukawa, Toshiya; Yagi, Takashi; Naganuma, Takao; Mitsushima, Masaru; Iida, Satoshi; Inaba, Yuka; Inoue, Hiroshi; Unoki-Kubota, Hiroyuki; Kaburagi, Yasushi; Asahara, Shun-Ichiro; Kido, Yoshiaki; Minami, Shiro; Kasuga, Masato; Matsumoto, Michihiro

Yano, Hiroyuki; Sakai, Mashito; Matsukawa, Toshiya; Yagi, Takashi; Naganuma, Takao; Mitsushima, Masaru; Iida, Satoshi; Inaba, Yuka; Inoue, Hiroshi; Unoki-Kubota, Hiroyuki; Kaburagi, Yasushi; Asahara, Shun-Ichiro; Kido, Yoshiaki; Minami, Shiro; Kasuga, Masato; Matsumoto, Michihiro.

Afiliação

Yano H; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Sakai M; Department of Bioregulation, Institute for Advanced Medical Sciences, Nippon Medical School, Kawasaki, 211-8533, Japan.
Matsukawa T; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Yagi T; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Naganuma T; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Mitsushima M; Department of Bioregulation, Institute for Advanced Medical Sciences, Nippon Medical School, Kawasaki, 211-8533, Japan.
Iida S; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Inaba Y; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Inoue H; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Unoki-Kubota H; Metabolism and Nutrition Research Unit, Innovative Integrated Bio-research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, 920-8641, Japan.
Kaburagi Y; Metabolism and Nutrition Research Unit, Innovative Integrated Bio-research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, 920-8641, Japan.
Asahara SI; Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Kido Y; Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Minami S; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Kasuga M; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Matsumoto M; Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, 654-0142, Japan.

Sci Rep ; 8(1): 14290, 2018 09 24.

Article em En | MEDLINE | ID: mdl-30250231

Assuntos

Gluconeogênese; Glucose/metabolismo; Hepatócitos/metabolismo; Insulina/metabolismo; Pró-Colágeno-Prolina Dioxigenase/metabolismo; Transdução de Sinais; Estresse Fisiológico; Animais; AMP Cíclico/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Ativação Enzimática; Regulação da Expressão Gênica; Glucagon/metabolismo; Humanos; Inflamação/genética; Inflamação/patologia; Interleucina-6/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Modelos Biológicos; NF-kappa B/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Pró-Colágeno-Prolina Dioxigenase/genética; Prolil Hidroxilases/metabolismo; Proteínas Repressoras/metabolismo; Fator de Transcrição STAT3/metabolismo; Fator de Transcrição STAT6/metabolismo; Transativadores/metabolismo; Resposta a Proteínas não Dobradas; Fatores de Transcrição de p300-CBP/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Transdução de Sinais / Pró-Colágeno-Prolina Dioxigenase / Hepatócitos / Gluconeogênese / Glucose / Insulina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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