[MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE].
Klin Med (Mosk)
; 95(2): 136-9, 2017.
Article
em Ru
| MEDLINE
| ID: mdl-30303666
ABSTRACT
Extrapineal and pineal melatonin is the marker of the aging rate of organism making it possible to characterize functional condition of the neuro-immuno-endocrine system. In this article we have used the new method for non-invasive diagnostics of melatonin expression in buccal epithelium and determination of the main melatonin metabolite 6-hydroxymelatonin sulfate (6-HMS) in urine of elderly people. Normal, impaired and enhanced melatonin expression was documented in 20.5%, 43.2% and 36.30% of the patients respectively. Such comprehensive melatonin and 6-COMT studies can be recommended for elderly patients with oncological, neurodegenerative, cardiovascular diseases, and ageing macular dystrophy. Moreover, melatonin expression analysis in buccal cells can be used for integral investigation of biorhythms in elderly people.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Doenças Cardiovasculares
/
Doenças Neurodegenerativas
/
Degeneração Macular
/
Melatonina
/
Mucosa Bucal
/
Neoplasias
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
Ru
Revista:
Klin Med (Mosk)
Ano de publicação:
2017
Tipo de documento:
Article