Primary sensory neurons expressing tropomyosin receptor kinase A in the rat trigeminal ganglion.
Neurosci Lett
; 690: 56-60, 2019 01 18.
Article
em En
| MEDLINE
| ID: mdl-30308237
ABSTRACT
Tropomyosin receptor kinase A (trkA), a high affinity receptor for nerve growth factor (NGF), has been implicated in neuronal survival, neurite outgrowth and inflammatory pain. So far, the characterization of the primary sensory neurons that express trkA, and are thus potentially affected by NGF, has remained incomplete. The goal of this study was to investigate the trkA-expressing neurons and fibers in the rat trigeminal ganglion and its sensory root using light- and electron-microscopic immunohistochemistry and quantitative analysis. TrkA-immunopositive (+) trigeminal neurons varied from small to large. Double immunofluorescent staining showed that about 28%, 33% and 3% of the trkA(+) neurons coexpressed SP, CGRP and IB4, respectively. About 11% of the trkA(+) neurons also coexpressed parvalbumin. Electron microscopy revealed that trkA was expressed in all types of fibers While the large majority of the trkA(+) fibers were unmyelinated (35.3%) and small myelinated (<20 µm2 in cross-sectional area; 45.5%), a still considerable fraction (19.2%) was large myelinated. These findings indicate that all types of trigeminal neurons (ones with unmyelinated, small myelinated or large myelinated fibers) may be regulated by NGF/trkA signaling.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Receptoras Sensoriais
/
Gânglio Trigeminal
/
Receptor trkA
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Coréia do Sul