Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling.

Bonomi, Massimiliano; Hanot, Samuel; Greenberg, Charles H; Sali, Andrej; Nilges, Michael; Vendruscolo, Michele; Pellarin, Riccardo

Bonomi, Massimiliano; Hanot, Samuel; Greenberg, Charles H; Sali, Andrej; Nilges, Michael; Vendruscolo, Michele; Pellarin, Riccardo.

Afiliação

Bonomi M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. Electronic address: mb2006@cam.ac.uk.
Hanot S; Institut Pasteur, Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, CNRS UMR 3528, C3BI USR 3756 CNRS & IP, Paris, France.
Greenberg CH; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Sciences, and California Institute for Quantitative Biomedical Sciences, University of California, San Francisco, CA 94158, USA.
Sali A; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Sciences, and California Institute for Quantitative Biomedical Sciences, University of California, San Francisco, CA 94158, USA.
Nilges M; Institut Pasteur, Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, CNRS UMR 3528, C3BI USR 3756 CNRS & IP, Paris, France.
Vendruscolo M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Pellarin R; Institut Pasteur, Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, CNRS UMR 3528, C3BI USR 3756 CNRS & IP, Paris, France. Electronic address: riccardo.pellarin@pasteur.fr.

Structure ; 27(1): 175-188.e6, 2019 01 02.

Article em En | MEDLINE | ID: mdl-30393052

Assuntos

Microscopia Crioeletrônica/métodos; Simulação de Dinâmica Molecular; Proteínas de Bactérias/química; Teorema de Bayes; Chaperonina 10/química; Chaperonina 60/química; Espectrometria de Massas/métodos; RNA Polimerase II/química

Palavras-chave

Gaussian mixture model; bayesian inference; cross-linking mass spectrometry; cryo-electron microscopy; data weighing; integrative structural modeling; macromolecular complexes; structural biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microscopia Crioeletrônica / Simulação de Dinâmica Molecular Tipo de estudo: Prognostic_studies Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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