[99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging.
Nanoscale
; 11(2): 541-551, 2019 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-30543234
ABSTRACT
Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems have received only limited attention so far. These studies involve the synthesis of a novel hydrophobic radio-imaging tracer consisting of a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate that can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in vivo. We provide details of the tracer synthesis, characterization of the rHDL/tracer complex, in vitro uptake, stability studies and in vivo application of this new radio-imaging approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traçadores Radioativos
/
Cintilografia
/
Tecnécio
/
Nanopartículas
/
Lipoproteínas HDL
/
Ácidos Nicotínicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
México