Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.
Medicine (Baltimore)
; 97(49): e13512, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30544450
ABSTRACT
BACKGROUND:
Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI.METHODS:
PubMed, Embase, and Web of Science databases were searched from inception to June 2018. Stroke and MI were considered as a composite endpoint. We calculated pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Subgroup and sensitivity analysis were performed to assess the potential sources of heterogeneity of the pooled estimation.RESULTS:
A total of 12 articles with 15 studies involving 3,701,199 participants were included in this meta-analysis. Of these, 14 studies on stroke and 12 on MI. Pooled analysis showed participants with AD experienced a significant increased risk of stroke (combined HR, 1.15; 95% CI, 1.08-1.22; Pâ=â.000) and MI (combined HR, 1.13; 95% CI, 1.02-1.24; Pâ=â.014), compared with participants without AD. The risk of stroke and MI was significant both in male subjects (stroke HR 1.33, 95% CI 1.14-1.56; MI HR 2.01, 95% CI 1.31-3.08), but not in female subjects (HR 1.02, 95% CI 0.77-1.35; MI HR 0.98, 95% CI 0.72-1.32). The results were more pronounced for ischemic stroke (HR 1.16, 95% CI 1.13-1.19) in the stratified with stroke type. Stratifying by AD type, the risk of stroke was significant in severe AD (HR 1.29, 95% CI 1.08-1.54) and moderate AD (HR 1.11, 95% CI 1.01-1.22) for MI.CONCLUSIONS:
AD is independently associated with an increased risk of stroke and MI, especially in male subjects and ischemic stroke and the risk is associated with the severity of AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Dermatite Atópica
/
Infarto do Miocárdio
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2018
Tipo de documento:
Article