The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.
Adv Protein Chem Struct Biol
; 114: 265-313, 2019.
Article
em En
| MEDLINE
| ID: mdl-30635083
ABSTRACT
SGTA is a co-chaperone that, in collaboration with the complex of BAG6/UBL4A/TRC35, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment. This work includes targeting tail-anchored proteins to their resident membranes, sorting of membrane and secretory proteins that mislocalize to the cytoplasm and endoplasmic reticulum-associated degradation of misfolded proteins. Since these functions are all vital for the cell's continued proteostasis, their disruption poses a threat to the cell, with a particular risk of protein aggregation, a phenomenon that underpins many diseases. Although the specific disease implications of machinery involved in quality control of hydrophobic substrates are poorly understood, here we summarize much of the available information on this topic.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
Problema de saúde:
1_doencas_nao_transmissiveis
Assunto principal:
Síndrome do Ovário Policístico
/
Viroses
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Proteínas de Transporte
/
Chaperonas Moleculares
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Doenças Neurodegenerativas
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Citosol
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Neoplasias
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Adv Protein Chem Struct Biol
Assunto da revista:
BIOLOGIA
/
BIOQUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido