A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica.
Korean J Parasitol
; 57(1): 1-8, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30840792
ABSTRACT
There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were characterized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory effects (P ≤ 0.001) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleukin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased (P ≤ 0.001). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and enhanced their lethal activity as evidenced by the in vitro experiments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Leishmania tropica
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Sistemas de Liberação de Medicamentos
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Sinergismo Farmacológico
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Antimoniato de Meglumina
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Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Korean J Parasitol
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Irã