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The TLR7 agonist imiquimod selectively inhibits IL-4-induced IgE production by suppressing IgG1/IgE class switching and germline ε transcription through the induction of BCL6 expression in B cells.
Yoon, Hee-Kyung; Shim, You-Sun; Kim, Pyeung-Hyeun; Park, Seok-Rae.
Afiliação
  • Yoon HK; Department of Microbiology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea.
  • Shim YS; Department of Microbiology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea.
  • Kim PH; Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Park SR; Department of Microbiology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea; Priority Research Center, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea. Electronic address: sr
Cell Immunol ; 338: 1-8, 2019 04.
Article em En | MEDLINE | ID: mdl-30850088
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Linfócitos B / Proteínas Proto-Oncogênicas c-bcl-6 / Receptor 7 Toll-Like / Imiquimode Limite: Animals Idioma: En Revista: Cell Immunol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Linfócitos B / Proteínas Proto-Oncogênicas c-bcl-6 / Receptor 7 Toll-Like / Imiquimode Limite: Animals Idioma: En Revista: Cell Immunol Ano de publicação: 2019 Tipo de documento: Article