Effect of a radiographic contrast agent on renal function in the rat. Comparison with equiosmolar mannitol.
Miner Electrolyte Metab
; 12(3): 157-60, 1986.
Article
em En
| MEDLINE
| ID: mdl-3088415
ABSTRACT
The renal effects of the radiographic contrast agent meglumine iothalamate (Conray; C) were evaluated in rats. C produced a 42% fall in glomerular filtration rate (p less than 0.05) and a 44% fall in effective renal plasma flow (p less than 0.05). The effects of C were blunted by both acute and chronic volume expansion. Equiosmolar mannitol produced similar hemodynamic responses as C. The fractional excretions of sodium and potassium were similar in rats given C or mannitol. The renal effects of C appear to be due to its hypertonicity. These effects may be modified by volume expansion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Iotalamato de Meglumina
/
Meios de Contraste
/
Rim
/
Manitol
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Miner Electrolyte Metab
Ano de publicação:
1986
Tipo de documento:
Article