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Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
Huang, Luyi; Li, Hui; Li, Linli; Niu, Lu; Seupel, Raina; Wu, Chengyong; Cheng, Wei; Chen, Chong; Ding, Bisen; Brennan, Paul E; Yang, Shengyong.
Afiliação
  • Huang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Li H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Li L; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy , Sichuan University , Sichuan 610041 , P. R. China.
  • Niu L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Seupel R; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K.
  • Wu C; Target Discovery Institute , University of Oxford , NDM Research Building, Roosevelt Drive , Oxford OX3 7FZ , U.K.
  • Cheng W; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Chen C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Ding B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Brennan PE; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R. China.
  • Yang S; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K.
J Med Chem ; 62(9): 4526-4542, 2019 05 09.
Article em En | MEDLINE | ID: mdl-30998845
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Pirróis / Inibidores Enzimáticos / Fatores de Transcrição de p300-CBP / Domínios Proteicos Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Pirróis / Inibidores Enzimáticos / Fatores de Transcrição de p300-CBP / Domínios Proteicos Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article