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Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient.
Ramdhan, N D; Blom, J; Sutcliffe, I C; Pereira-Ribeiro, P M A; Santos, C S; Mattos-Guaraldi, A L; Burkovski, A; Sangal, V.
Afiliação
  • Ramdhan ND; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UK.
  • Blom J; Bioinformatics and Systems Biology, Justus-Liebig-Universität, Gießen, Germany.
  • Sutcliffe IC; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UK.
  • Pereira-Ribeiro PMA; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University-UERJ, Rio de Janeiro, Brazil.
  • Santos CS; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University-UERJ, Rio de Janeiro, Brazil.
  • Mattos-Guaraldi AL; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University-UERJ, Rio de Janeiro, Brazil.
  • Burkovski A; Department of Microbiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Sangal V; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UK.
New Microbes New Infect ; 30: 100544, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31061711
ABSTRACT
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: New Microbes New Infect Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: New Microbes New Infect Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido