PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis.
Physiol Rep
; 7(10): e14078, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-31102342
ABSTRACT
Sepsis-associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis-associated AKI are poorly understood. Previous research has demonstrated that peroxisome proliferator-activated receptor α (PPARα) expression is associated with reduced organ system failure in sepsis. Using an experimental model of polymicrobial sepsis, we demonstrate that mice deficient in PPARα have worse kidney function, which is likely related to reduced fatty acid oxidation and increased inflammation. Ultrastructural evaluation with electron microscopy reveals that the proximal convoluted tubule is specifically injured in septic PPARα deficient mice. In this experimental group, serum metabolomic analysis reveals unanticipated metabolic derangements in tryptophan-kynurenine-NAD+ and pantothenate pathways. We also show that a subgroup of children with sepsis whose genome-wide expression profiles are characterized by repression of the PPARα signaling pathway has increased incidence of severe AKI. These findings point toward interesting associations between sepsis-associated AKI and PPARα-driven fatty acid metabolism that merit further investigation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
4_TD
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de saúde:
1_doencas_nao_transmissiveis
/
2_muertes_prevenibles
/
4_sepsis
/
6_kidney_renal_pelvis_ureter_cancer
/
7_infections
Assunto principal:
Sepse
/
Mediadores da Inflamação
/
PPAR alfa
/
Metabolismo Energético
/
Injúria Renal Aguda
/
Rim
/
Nefrite
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Physiol Rep
Ano de publicação:
2019
Tipo de documento:
Article