Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature.

ABSTRACT

PURPOSE: Propafenone hydrochloride has been widely used for the treatment of supraventricular and ventricular arrhythmias. We present a case report of an 81-year-old patient with propafenone-associated gross hematuria. METHODS: The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality. We also performed a literature search to find publications that report propafenone-associated gross hematuria. FINDINGS: The Naranjo scale generated a score of 6, suggesting a probable association between gross hematuria and propafenone therapy. Thirteen publications that reported an association between gross hematuria and propafenone administration were found. IMPLICATIONS A probable association exists between gross hematuria and propafenone.