Stabilin Receptors: Role as Phosphatidylserine Receptors.
Biomolecules
; 9(8)2019 08 20.
Article
em En
| MEDLINE
| ID: mdl-31434355
ABSTRACT
Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular Neuronais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomolecules
Ano de publicação:
2019
Tipo de documento:
Article