Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways.

Blomme, Benoit; Deroanne, Christophe; Hulin, Alexia; Lambert, Charles; Defraigne, Jean-Olivier; Nusgens, Betty; Radermecker, Marc; Colige, Alain

Blomme, Benoit; Deroanne, Christophe; Hulin, Alexia; Lambert, Charles; Defraigne, Jean-Olivier; Nusgens, Betty; Radermecker, Marc; Colige, Alain.

Afiliação

Blomme B; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Deroanne C; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Hulin A; Laboratory of Cardiology, GIGA-Cardiovascular Sciences, B34, University of Liège, 4000 Sart- Tilman, Belgium.
Lambert C; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Defraigne JO; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Nusgens B; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Radermecker M; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium; Department of Human Anatomy, B23, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Colige A; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium. Electronic address: acolige@uliege.be.

J Mol Cell Cardiol ; 135: 149-159, 2019 10.

Article em En | MEDLINE | ID: mdl-31442470

Assuntos

Estenose da Valva Aórtica/genética; Calcinose/genética; Fibrose/genética; Valva Mitral/metabolismo; Valva Aórtica/metabolismo; Valva Aórtica/patologia; Estenose da Valva Aórtica/patologia; Calcinose/patologia; Fibrose/patologia; Humanos; Sistema de Sinalização das MAP Quinases/genética; Valva Mitral/patologia; Estresse Mecânico; Transativadores/genética; Quinases Associadas a rho/genética; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

CTGF/CCN2; Heart valve disease; MMV; MRTF-A; Mechanical strain; RhoGTPases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estenose da Valva Aórtica / Fibrose / Calcinose / Valva Mitral Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica

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