Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection.
Mem Inst Oswaldo Cruz
; 82 Suppl 4: 237-41, 1987.
Article
em En
| MEDLINE
| ID: mdl-3151097
ABSTRACT
We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Schistosoma japonicum
/
Esquistossomose Japônica
/
Imunoglobulina E
/
Anticorpos Anti-Helmínticos
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Japão