Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus.
Elife
; 82019 10 17.
Article
em En
| MEDLINE
| ID: mdl-31621584
ABSTRACT
In the fungus Ustilago maydis, sexual pheromones elicit mating resulting in an infective filament able to infect corn plants. Along this process a G2 cell cycle arrest is mandatory. Such as cell cycle arrest is initiated upon the pheromone recognition in each mating partner, and sustained once cell fusion occurred until the fungus enter the plant tissue. We describe that the initial cell cycle arrest resulted from inhibition of the nuclear transport of the mitotic inducer Cdc25 by targeting its importin, Kap123. Near cell fusion to take place, the increase on pheromone signaling promotes Cdc25 degradation, which seems to be important to ensure the maintenance of the G2 cell cycle arrest to lead the formation of the infective filament. This way, premating cell cycle arrest is linked to the subsequent steps required for establishment of the infection. Disabling this connection resulted in the inability of fungal cells to infect plants.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ustilago
/
Proteínas Fúngicas
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Regulação Fúngica da Expressão Gênica
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Fosfatases cdc25
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Beta Carioferinas
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Pontos de Checagem da Fase G2 do Ciclo Celular
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Fator de Acasalamento
Idioma:
En
Revista:
Elife
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha