Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
Eur Rev Med Pharmacol Sci
; 23(19): 8533-8539, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31646585
ABSTRACT
OBJECTIVE:
Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease of the central nervous system. In this study, we aimed to investigate plasma ZCCHC14 expression and its correlation with the diagnosis, prognosis, and clinical features of ICH. PATIENTS ANDMETHODS:
The plasma levels of ZCCHC14, TNF-α, IL-6, and IL-10 were dynamically detected among 130 ICH patients and 60 corresponding healthy subjects. A receiver operating characteristic (ROC) curve was used for the statistical analysis of the diagnostic and prognostic efficacy of ICH.RESULTS:
Hypertension (p = 0.005), ARB application (p = 0.014), ZCCHC14 level (p < 0.001), TNF-α (p < 0.001), IL-6 (p < 0.001), and IL-10 (p < 0.001) were found to be different between ICH patients and healthy controls. Multiple logistic regression analysis indicated that ZCCHC14 levels at admission were significantly different between the two groups (p = 0.002, OR = 0.440, 95% CI 0.290-0.718). Plasma ZCCHC14 levels dynamically changed, increasing at admission, and peaking on day 7. ZCCHC14 was a potential diagnostic marker for ICH (AUC = 0.953, p < 0.0001, 95% CI 0.901-1.004) with a specificity and sensitivity of 84.6% and 95.5%, respectively. The plasma ZCCHC14 level was negatively correlated with IL-6 concentration (p = 0.024, r = -0.311) but was positively correlated with IL-10 concentration (p = 0.041, r = 0.298). Furthermore, the plasma ZCCHC14 level was correlated with hypertension (p = 0.005), GOS (p = 0.025), bleeding volume (p < 0.001), midline shift (p = 0.003), and poor outcome (p = 0.006). The low ZCCHC14 expression group had poorer outcomes (death or severe disability) than high ZCCHC14 expression group (Breslow, p < 0.001).CONCLUSIONS:
We found that the plasma ZCCHC14 level might be a potential biomarker for both the early diagnosis of and prediction of outcomes in ICH.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_cardiovascular_diseases
/
6_cerebrovascular_disease
Assunto principal:
Proteínas Nucleares
/
Hemorragia Cerebral
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article