The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.
PLoS Pathog
; 15(11): e1007634, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31682641
ABSTRACT
Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a transcriptional program with potent antiviral activity, driven by E74-like ETS transcription factor 1 (ELF1). Using microscopy to quantify viral infection over time, we found that ELF1 inhibits eight diverse RNA and DNA viruses after multi-cycle replication. Elf1 deficiency results in enhanced susceptibility to influenza A virus infections in mice. ELF1 does not feed-forward to induce interferons, and ELF1's antiviral effect is not abolished by the absence of STAT1 or by inhibition of JAK phosphorylation. Accordingly, comparative expression analyses by RNA-seq revealed that the ELF1 transcriptional program is distinct from interferon signatures. Thus, ELF1 provides an additional layer of the innate host response, independent from the action of type I interferons.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Vírus da Influenza A
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Fatores de Transcrição
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Replicação Viral
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Proteínas Nucleares
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Interferon Tipo I
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Regulação da Expressão Gênica
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Infecções por Orthomyxoviridae
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
PLoS Pathog
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos