Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.

Aspernig, Helena; Heimbucher, Thomas; Qi, Wenjing; Gangurde, Dipak; Curic, Sedric; Yan, Yijian; Donner von Gromoff, Erika; Baumeister, Ralf; Thien, Antje

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.

Aspernig, Helena; Heimbucher, Thomas; Qi, Wenjing; Gangurde, Dipak; Curic, Sedric; Yan, Yijian; Donner von Gromoff, Erika; Baumeister, Ralf; Thien, Antje.

Afiliação

Aspernig H; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Heimbucher T; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Qi W; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Gangurde D; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Curic S; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Yan Y; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Donner von Gromoff E; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.
Baumeister R; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany; Center for Biochemistry and Molecular Cell Research, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany; Signalling Research Centres B
Thien A; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Baden-Wuerttemberg, Germany.

Cell Rep ; 29(6): 1399-1409.e5, 2019 11 05.

Article em En | MEDLINE | ID: mdl-31693882

Assuntos

Caenorhabditis elegans/metabolismo; Alvo Mecanístico do Complexo 2 de Rapamicina/metabolismo; Mitocôndrias/metabolismo; Mitofagia/genética; Animais; Caenorhabditis elegans/embriologia; Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Alvo Mecanístico do Complexo 2 de Rapamicina/genética; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Interferência de RNA; Proteína Companheira de mTOR Insensível à Rapamicina/genética; Proteína Companheira de mTOR Insensível à Rapamicina/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/genética

Palavras-chave

ROS; SGK-1; autophagy; mTOR; mTORC2; mammalian target of rapamycin; mitochondria; mitophagy; reactive oxygen species; serum glucocorticoid-regulated kinase 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans / Mitofagia / Alvo Mecanístico do Complexo 2 de Rapamicina / Mitocôndrias Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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