Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved.
Gut Microbes
; 12(1): 1690364, 2020 11 09.
Article
em En
| MEDLINE
| ID: mdl-31760871
ABSTRACT
Triclocarban (TCC) is a widely used antimicrobial ingredient in consumer products and is a ubiquitous contaminant in the environment. In 2016, the FDA removed TCC from over-the-counter handwashing products, but this compound is still approved for use in many other personal care products. A better understanding of its impact on human health could lead to significant impact for public health and regulatory policies. Here we show that exposure to low-dose TCC exaggerated the severity of colitis and exacerbated the development of colitis-associated colon tumorigenesis, via gut microbiota-dependent mechanisms. Exposure to TCC increased dextran sodium sulfate (DSS)- and interleukin 10 (IL-10) knockout-induced colitis, and exaggerated azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice. Regarding the mechanisms, TCC exposure reduced the diversity and altered the composition of gut microbiota and failed to promote DSS-induced colitis in mice lacking the microbiota, supporting that the presence of the microbiota is critical for the pro-colitis effects of TCC. Together, these results support TCC could be a novel risk factor for colitis and colitis-associated colon cancer, and further regulatory policies on this compound could be needed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_zoonosis
Assunto principal:
Carbanilidas
/
Transformação Celular Neoplásica
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Colite
/
Neoplasias do Colo
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Microbioma Gastrointestinal
/
Anti-Infecciosos Locais
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Gut Microbes
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos