Stanniocalcin-1 protein expression profile and mechanisms in proliferation and cell death pathways in prostate cancer.
Mol Cell Endocrinol
; 502: 110659, 2020 02 15.
Article
em En
| MEDLINE
| ID: mdl-31816356
ABSTRACT
Prostate cancer (PCa) is one of the most prevalent male tumours. Stanniocalcin-1 (STC1) is a glycoprotein and, although the role of STC1 in human cancer is poorly understood, it is suggested to be involved in the development and progression of different neoplasms. This study investigated the protein expression profile of STC1 in PCa and benign prostatic hyperplasia (BPH) samples and STC1 signalling during cell proliferation and cell death in vitro using cell lines. We found higher levels of STC1 in PCa when compared to BPH tissue and that STC1 inhibited forskolin stimulation of cAMP in PC-3 cells. A monoclonal antibody against STC1 was effective in reducing cell proliferation, in promoting cell cycle arrest, and in increasing apoptosis in the same cells. Since STC1 acts as a regulator of prostatic tissue signalling, we suggest that this protein is a novel candidate biomarker for prostate tumour clinical progression and a potential therapeutic target.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_prostate_cancer
Assunto principal:
Hiperplasia Prostática
/
Neoplasias da Próstata
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Colforsina
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Glicoproteínas
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Biomarcadores Tumorais
Limite:
Humans
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Male
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil