Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda.
AAS Open Res
; 2: 17, 2019.
Article
em En
| MEDLINE
| ID: mdl-31819922
ABSTRACT
Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa, and a significant cause of morbidity; it is a priority for vaccine development. A controlled human infection model for Schistosoma mansoni (CHI-S) with potential to accelerate vaccine development has been developed among naïve volunteers in the Netherlands. Because responses both to infections and candidate vaccines are likely to differ between endemic and non-endemic settings, we propose to establish a CHI-S in Uganda where Schistosoma mansoni is endemic. As part of a "road-map" to this goal, we have undertaken a risk assessment. We identified risks related to importing of laboratory vector snails and schistosome strains from the Netherlands to Uganda; exposure to natural infection in endemic settings concurrently with CHI-S studies, and unfamiliarity of the community with the nature, risks and rationale for CHI. Mitigating strategies are proposed. With careful implementation of the latter, we believe that CHI-S can be implemented safely in Uganda. Our reflections are presented here to promote feedback and discussion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
3_ND
Problema de saúde:
1_doencas_transmissiveis
/
3_neglected_diseases
/
3_schistosomiasis
/
3_zoonosis
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
AAS Open Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Holanda