Drug design strategies with metal-hydroxyquinoline complexes.
Expert Opin Drug Discov
; 15(3): 383-390, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31829757
ABSTRACT
Introduction:
8-hydroxyquinoline derivatives and their complexes with transition metals are the subject of many studies due to their anticancer, anti-inflammatory, anti-infective, and antidiabetic activities.Areas covered Within this article, the authors review the synthesis and current applications of metal-8-hydroxyquinoline complexes in drug design with a critical overview of the latest advancements in the field.Expert opinion Metal-8-hydroxyquinoline complexes are especially interesting because of their simple synthesis procedures and possible applications in modern medicine. The complexation between transition metal ions and 8-hydroxyquinoline or its derivatives is achieved via their O and N atoms. The main problem with their application is lipophilicity. This particular property has an impact on their solubility, biological activity, transport through the cell membrane, construction of the complex with a receptor, and development of drugs. Furthermore, in the treatment of neurodegenerative diseases and brain cancers, the passage of the complexes through the blood-brain barrier can only be ensured through novel drug design.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Oxiquinolina
/
Complexos de Coordenação
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Expert Opin Drug Discov
Ano de publicação:
2020
Tipo de documento:
Article