Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the French cooperative thoracic intergroup (IFCT) biomarkers France project.

Beau-Faller, Michèle; Pencreach, Erwan; Leduc, Charlotte; Blons, Hélène; Merlio, Jean-Philippe; Bringuier, Pierre-Paul; de Fraipont, Florence; Escande, Fabienne; Lemoine, Antoinette; Ouafik, L'Houcine; Denis, Marc; Hofman, Paul; Lacave, Roger; Melaabi, Samia; Langlais, Alexandra; Missy, Pascale; Morin, Franck; Moro-Sibilot, Denis; Barlesi, Fabrice; Cadranel, Jacques

Beau-Faller, Michèle; Pencreach, Erwan; Leduc, Charlotte; Blons, Hélène; Merlio, Jean-Philippe; Bringuier, Pierre-Paul; de Fraipont, Florence; Escande, Fabienne; Lemoine, Antoinette; Ouafik, L'Houcine; Denis, Marc; Hofman, Paul; Lacave, Roger; Melaabi, Samia; Langlais, Alexandra; Missy, Pascale; Morin, Franck; Moro-Sibilot, Denis; Barlesi, Fabrice; Cadranel, Jacques.

Afiliação

Beau-Faller M; Laboratory of Biochemistry and Molecular Biology, Centre Hospitalier Universitaire de Strasbourg, Hôpital de Hautepierre, Strasbourg, France; IRFAC UMR-S1113, Inserm, Université de Strasbourg, Strasbourg, France. Electronic address: michele.faller@chru-strasbourg.fr.
Pencreach E; IRFAC UMR-S1113, Inserm, Université de Strasbourg, Strasbourg, France.
Leduc C; Chest Department, Centre Hospitalier Universitaire de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.
Blons H; HEGP, Biochimie UF de Pharmacogénétique et Oncologie Moléculaire, Paris, France.
Merlio JP; Department of Pathology and Tumor Biology, CHU and University Bordeaux, Hôpital Haut-Lévêque, Pessac, France.
Bringuier PP; Centre de Biologie et Pathologie Est, Service d'Anatomie et de Cytologie Pathologique, Hospices Civils de Lyon et Université Claude Bernard Lyon 1, Lyon, France.
de Fraipont F; UM de Génétique moléculaire: Maladies Héréditaires et Oncologie, Pôle de Biologie et Pathologie, CHU Grenoble Alpes, Grenoble, France; UGA/INSERM U1209/CNRS 5309-Institute for Advanced Biosciences-Université Grenoble Alpes, Grenoble, France.
Escande F; Laboratoire de Biochimie et Biologie moléculaire, CHRU Lille, LILLE, France.
Lemoine A; Biochimie et Oncogénétique INSERM UMR-S1193, Hôpital Paul Brousse, Hôpitaux Universitaires Paris-Sud, Villejuif, France.
Ouafik L; Aix Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, Faculté de Médecine Secteur Nord, Service de Transfert d'Oncologie Biologique, Marseille, France.
Denis M; Laboratoire de Biochimie et Plateforme de Génétique Moléculaire des Cancers, CHU Nantes, Nantes, France.
Hofman P; Université Côte d'Azur, and FHU OncoAge, Laboratory of Clinical and Experimental Pathology, Inserm U1081/CNRS 7284, and Hospital-Integrated Biobank (BB-0033-00025) Pasteur Hospital, Nice, France.
Lacave R; Faculté de Médecine Sorbonne Université, and Groupe Hospitalier HUEP, Hôpital Tenon, Unité de Génomique des Tumeurs Solides, Assistance Publique-Hôpitaux de Paris, France.
Melaabi S; Service de Génétique, Unité de Pharmacogénomique, Institut Curie, Paris, France.
Langlais A; Department of Biostatistics, French Cooperative Thoracic Intergroup, Paris, France.
Missy P; Clinical Research Unit, French Cooperative Thoracic Intergroup, Paris, France.
Morin F; Clinical Research Unit, French Cooperative Thoracic Intergroup, Paris, France.
Moro-Sibilot D; Unité d'Oncologie Thoracique, Service Hospitalier Universitaire Pneumologie Physiologie Pôle Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France.
Barlesi F; Aix Marseille University, CNRS, INSERM, CRCM, Assistance Publique Hôpitaux de Marseille, Marseille, France.
Cadranel J; AP-HP, Hôpital Tenon, Service de Pneumogie, GRC 04 Theranoscan, Sorbonne Université, Paris, France.

Lung Cancer ; 140: 19-26, 2020 02.

Article em En | MEDLINE | ID: mdl-31841714

Assuntos

Carcinoma Pulmonar de Células não Pequenas/patologia; Neoplasias Pulmonares/patologia; Mutação; Inibidores de Proteínas Quinases/uso terapêutico; Adenocarcinoma de Pulmão/tratamento farmacológico; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/patologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Biomarcadores Tumorais/genética; Carcinoma de Células Grandes/tratamento farmacológico; Carcinoma de Células Grandes/genética; Carcinoma de Células Grandes/patologia; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/patologia; Resistencia a Medicamentos Antineoplásicos; Receptores ErbB/genética; Feminino; Seguimentos; França; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Masculino; Pessoa de Meia-Idade; Prognóstico; Estudos Retrospectivos; Taxa de Sobrevida

Palavras-chave

Droplet digital PCR (ddPCR); EGFR mutation; Non-small cell lung cancer (NSCLC); T790M; Variant allele frequency (VAF)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Inibidores de Proteínas Quinases / Neoplasias Pulmonares / Mutação Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article

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