Quantifying between-Host Transmission in Influenza Virus Infections.
Cold Spring Harb Perspect Med
; 10(8)2020 08 03.
Article
em En
| MEDLINE
| ID: mdl-31871239
ABSTRACT
The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity of virus variants that reach a new host and establish an infection. This sharp reduction in the virus population at transmission--the transmission bottleneck--is significant to the evolution of influenza virus and to its epidemic and pandemic potential. This review describes transmission bottlenecks and their effect on the diversity and evolution of influenza virus. It also reviews the methods for calculating and predicting bottleneck sizes and highlights the host and viral determinants of influenza transmissibility.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_enfermedades_transmissibles
Assunto principal:
Orthomyxoviridae
/
Replicação Viral
/
Influenza Humana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos