Molecular Basis for Metabolic Regioselectivity and Mechanism of Cytochrome P450s toward Carcinogenic 4-(Methylnitrosamino)-(3-pyridyl)-1-butanone.

Ma, Guangcai; Yu, Haiying; Xu, Xiaoqin; Geng, Liming; Wei, Xiaoxuan; Wen, Jiale; Wang, Zhiguo

Ma, Guangcai; Yu, Haiying; Xu, Xiaoqin; Geng, Liming; Wei, Xiaoxuan; Wen, Jiale; Wang, Zhiguo.

Afiliação

Ma G; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Yu H; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Xu X; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Geng L; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Wei X; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Wen J; College of Geography and Environmental Sciences , Zhejiang Normal University , Jinhua 321004 , China.
Wang Z; Institute of Ageing Research, School of Medicine , Hangzhou Normal University , Hangzhou 311121 , China.

Chem Res Toxicol ; 33(2): 436-447, 2020 02 17.

Article em En | MEDLINE | ID: mdl-31889441

Assuntos

Carcinógenos/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Nitrosaminas/metabolismo; Carcinógenos/química; Teoria da Densidade Funcional; Modelos Moleculares; Estrutura Molecular; Nitrosaminas/química; Estereoisomerismo; Termodinâmica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinógenos / Sistema Enzimático do Citocromo P-450 / Nitrosaminas Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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