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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Hanson, Jesse E; Ma, Keran; Elstrott, Justin; Weber, Martin; Saillet, Sandrine; Khan, Abdullah S; Simms, Jeffrey; Liu, Benjamin; Kim, Thomas A; Yu, Gui-Qiu; Chen, Yelin; Wang, Tzu-Ming; Jiang, Zhiyu; Liederer, Bianca M; Deshmukh, Gauri; Solanoy, Hilda; Chan, Connie; Sellers, Benjamin D; Volgraf, Matthew; Schwarz, Jacob B; Hackos, David H; Weimer, Robby M; Sheng, Morgan; Gill, T Michael; Scearce-Levie, Kimberly; Palop, Jorge J.
Afiliação
  • Hanson JE; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA. Electronic address: hanson.jesse@gene.com.
  • Ma K; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Elstrott J; Department of Biomedical Imaging, Genentech Inc., South San Francisco, CA 94080, USA.
  • Weber M; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Saillet S; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Khan AS; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Simms J; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Liu B; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Kim TA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Yu GQ; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Chen Y; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Wang TM; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Jiang Z; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Liederer BM; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.
  • Deshmukh G; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.
  • Solanoy H; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Chan C; Department of Pharmaceuticals, Genentech Inc., South San Francisco, CA 94080, USA.
  • Sellers BD; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  • Volgraf M; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  • Schwarz JB; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  • Hackos DH; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Weimer RM; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA; Department of Biomedical Imaging, Genentech Inc., South San Francisco, CA 94080, USA.
  • Sheng M; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Gill TM; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Scearce-Levie K; Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  • Palop JJ; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jorge.palop@gladstone.ucsf.edu.
Cell Rep ; 30(2): 381-396.e4, 2020 01 14.
Article em En | MEDLINE | ID: mdl-31940483
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Encéfalo / Epilepsias Mioclônicas / Receptores de N-Metil-D-Aspartato / Cognição / Ciclopropanos / Doença de Alzheimer / Nitrilas Limite: Animals / Humans / Male Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Encéfalo / Epilepsias Mioclônicas / Receptores de N-Metil-D-Aspartato / Cognição / Ciclopropanos / Doença de Alzheimer / Nitrilas Limite: Animals / Humans / Male Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article