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Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Zwicker, Jeffery D; Smith, David; Guerra, Alfredo J; Hitchens, Jacob R; Haug, Nicole; Vander Roest, Steve; Lee, Pil; Wen, Bo; Sun, Duxin; Wang, Lu; Keep, Richard F; Xiang, Jianming; Carruthers, Vern B; Larsen, Scott D.
Afiliação
  • Zwicker JD; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Smith D; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Guerra AJ; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Hitchens JR; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Haug N; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Vander Roest S; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Lee P; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wen B; Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun D; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang L; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Keep RF; Pharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Xiang J; Pharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Carruthers VB; Pharmacokinetics Core, Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Larsen SD; Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109, United States.
ACS Chem Neurosci ; 11(16): 2450-2463, 2020 08 19.
Article em En | MEDLINE | ID: mdl-32027110
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 / 3_ND Problema de saúde: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_zoonosis Assunto principal: Toxoplasma / Toxoplasmose Limite: Animals / Humans Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 / 3_ND Problema de saúde: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_zoonosis Assunto principal: Toxoplasma / Toxoplasmose Limite: Animals / Humans Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos