Synergistic Interactions of Indole-2-Carboxamides and ß-Lactam Antibiotics against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Article
em En
| MEDLINE
| ID: mdl-32041716
ABSTRACT
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the ß-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_tuberculosis
Assunto principal:
Beta-Lactamas
/
Mycobacterium abscessus
/
Indóis
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
França