Your browser doesn't support javascript.
loading
Synergistic Interactions of Indole-2-Carboxamides and ß-Lactam Antibiotics against Mycobacterium abscessus.
Raynaud, Clément; Daher, Wassim; Roquet-Banères, Françoise; Johansen, Matt D; Stec, Jozef; Onajole, Oluseye K; Ordway, Diane; Kozikowski, Alan P; Kremer, Laurent.
Afiliação
  • Raynaud C; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
  • Daher W; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
  • Roquet-Banères F; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
  • Johansen MD; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
  • Stec J; Department of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, California, USA.
  • Onajole OK; Department of Biological, Physical and Health Sciences, Roosevelt University, Chicago, Illinois, USA.
  • Ordway D; Colorado State University, Department of Microbiology, Immunology & Pathology, Mycobacteria Research Laboratory, Fort Collins, Colorado, USA.
  • Kozikowski AP; StarWise Therapeutics LLC, Chicago, Illinois, USA.
  • Kremer L; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France laurent.kremer@irim.cnrs.fr.
Antimicrob Agents Chemother ; 64(5)2020 04 21.
Article em En | MEDLINE | ID: mdl-32041716
ABSTRACT
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the ß-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_tuberculosis Assunto principal: Beta-Lactamas / Mycobacterium abscessus / Indóis / Antibacterianos Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_tuberculosis Assunto principal: Beta-Lactamas / Mycobacterium abscessus / Indóis / Antibacterianos Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França