The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis.
Hematology
; 25(1): 85-90, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32063160
ABSTRACT
Objective:
This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia.Methods:
Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12.Results:
Total five studies with 304 aplastic anemia patients and 588 controls were included. The statistically significant results were found in the following models allele genetic model (T vs A OR = 2.1749, 95% CI = 1.6825-2.8114, P < 0.01), additive genetic model (TA vs AA OR = 2.1071, 95% CI = 1.3962-3.1799, P < 0.01; TT vs AA OR = 4.5788, 95% CI = 2.6606-7.8797, P < 0.01), recessive genetic model (TT vs AA + TA OR = 2.5579, 95% = 1.6680-3.9226, P < 0.01), dominant genetic model (TT + TA vs AA OR = 2.5599, 95% = 1.7424-3.7611, P < 0.01), the results suggested that the increased occurrence risk of aplastic anemia is significantly associated with the IFN-γ polymorphism.Conclusions:
Patients with IFN-γ genotype carrying allele T have higher occurrence risk of aplastic anemia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon gama
/
Polimorfismo de Nucleotídeo Único
/
Anemia Aplástica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Hematology
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article