A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities.
Cancer Res
; 80(5): 927-928, 2020 03 01.
Article
em En
| MEDLINE
| ID: mdl-32122905
ABSTRACT
Radiotherapy is a critical component of many current, curative cancer treatments, yet it is accompanied by unavoidable irradiation of normal tissues. Abdominal and pelvic radiation almost always results in some dose delivered to the bowel with deleterious effects to the small and large intestines. While the likelihood of enteritis is dose dependent, there is also considerable variation between patients in both the extent of symptoms of enteritis as well as their duration. In this article, Martin and colleagues hypothesized that the radiation sensitivity of intestinal organoids could predict the sensitivity of individual patients to enteritis and have taken the first steps to develop such an assay.See related article by Martin et al., p. 1219.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organoides
/
Enterite
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido