Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-&#954;B p65 Nuclear Translocation and the Ubiquitination and Degradation of I&#954;B&#945;.

Hu, Xiaolei; Zhang, Hengyan; Zhuang, Langen; Jin, Guoxi; Yang, Qingqing; Li, Min; Sun, Weihua; Chen, Fengling

Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα.

Hu, Xiaolei; Zhang, Hengyan; Zhuang, Langen; Jin, Guoxi; Yang, Qingqing; Li, Min; Sun, Weihua; Chen, Fengling.

Afiliação

Hu X; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Zhang H; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Zhuang L; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Jin G; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Yang Q; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Li M; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Sun W; Department of Endocrinology, The First Afï¬liated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.
Chen F; Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China.

Drug Des Devel Ther ; 14: 795-810, 2020.

Article em En | MEDLINE | ID: mdl-32158197

Assuntos

Transporte Ativo do Núcleo Celular; Núcleo Celular/metabolismo; Diabetes Mellitus Experimental/metabolismo; Inflamação/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; NF-kappa B/metabolismo; Proteínas/metabolismo; Ubiquitinação; Animais; Células Cultivadas; Células HEK293; Humanos; Lipopolissacarídeos/farmacologia; Macrófagos/metabolismo; Masculino; Camundongos; Proteínas/antagonistas & inibidores; Proteínas/genética; Células RAW 264.7; RNA Interferente Pequeno/farmacologia; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

IκBα; NF-κB; diabetes; diabetic complications; macrophage; ubiquitin-fold modifier-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Núcleo Celular / NF-kappa B / Transporte Ativo do Núcleo Celular / Diabetes Mellitus Experimental / Ubiquitinação / Inibidor de NF-kappaB alfa / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Drug Des Devel Ther Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article

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