Vitamin C and inflammatory cytokine levels in elective total knee arthroplasty.
Nutr Health
; 26(2): 87-91, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32228134
ABSTRACT
BACKGROUND:
Vitamin C levels are decreased in arthritis patients and reduced levels following surgery may impair adequate healing.AIM:
This study measured changes in vitamin C and inflammatory markers in patients undergoing total knee arthroplasty (TKA).METHODS:
Venous blood samples were collected from 10 patients during the preoperative to postoperative period. Vitamin C, interleukin-1ß, interleukin-6 (IL-6), and C-reactive protein (CRP) levels were measured using various assays.RESULTS:
No significant changes in vitamin C levels were measured. However, all participants had suboptimal preoperative vitamin C levels and 90% had suboptimal levels postoperatively. IL-6 and CRP levels significantly increased during the immediate postoerative period.CONCLUSION:
There was a rise in inflammation following TKA while vitamin C levels did not significantly change during this short study period. Of note, every patient had suboptimal vitamin C levels prior to surgery and 90% continued with suboptimal levels two days postoperatively.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Ácido Ascórbico
/
Citocinas
/
Artroplastia do Joelho
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nutr Health
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos