Model-based design and control of a small-scale integrated continuous end-to-end mAb platform.

Gomis-Fons, Joaquín; Schwarz, Hubert; Zhang, Liang; Andersson, Niklas; Nilsson, Bernt; Castan, Andreas; Solbrand, Anita; Stevenson, Joanne; Chotteau, Véronique

Gomis-Fons, Joaquín; Schwarz, Hubert; Zhang, Liang; Andersson, Niklas; Nilsson, Bernt; Castan, Andreas; Solbrand, Anita; Stevenson, Joanne; Chotteau, Véronique.

Afiliação

Gomis-Fons J; Department of Chemical Engineering, Lund University, Lund, Sweden.
Schwarz H; Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Zhang L; Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Andersson N; Department of Chemical Engineering, Lund University, Lund, Sweden.
Nilsson B; Department of Chemical Engineering, Lund University, Lund, Sweden.
Castan A; GE Healthcare Life Sciences, Uppsala, Sweden.
Solbrand A; GE Healthcare Life Sciences, Uppsala, Sweden.
Stevenson J; Cobra Biologics, Analytical Development, Södertälje, Sweden.
Chotteau V; Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.

Biotechnol Prog ; 36(4): e2995, 2020 07.

Article em En | MEDLINE | ID: mdl-32233078

Assuntos

Anticorpos Monoclonais/biossíntese; Reatores Biológicos; Cromatografia por Troca Iônica/métodos; Proteína Estafilocócica A/química; Animais; Anticorpos Monoclonais/imunologia; Células CHO; Cricetinae; Cricetulus; Filtração

Palavras-chave

end-to-end continuous bioprocessing; monoclonal antibody; perfusion bioreactor; process integration; process modelling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Estafilocócica A / Cromatografia por Troca Iônica / Reatores Biológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotechnol Prog Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia

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