A self-assembled lysinated perylene diimide film as a multifunctional material for neural interfacing.
J Mater Chem B
; 4(17): 2921-2932, 2016 May 07.
Article
em En
| MEDLINE
| ID: mdl-32262970
ABSTRACT
We report the design, synthesis and structure-property investigation of a new perylene diimide material (PDI-Lys) bearing lysine end substituents. Water processed films of PDI-Lys were prepared and their self-assembly, morphology and electrical properties in both inert and air environments were theoretically and experimentally investigated. With the aim of evaluating the potential of PDI-Lys as a biocompatible and functional neural interface for organic bioelectronic applications, its electrochemical impedance as well as the adhesion and viability properties of primary neurons on the PDI-Lys films were studied. By combining theoretical calculations and electrical measurements we show that due to conversion between neutral and zwitterionic anions, the PDI-Lys film conductivity increased significantly upon passing from air to an inert atmosphere, reaching a maximum value of 6.3 S m-1. We also show that the PDI-Lys film allows neural cell adhesion and neuron differentiation and decreases up to 5 times the electrode/solution impedance in comparison to a naked gold electrode. The present study introduces an innovative, water processable conductive film usable in organic electronics and as a putative neural interface.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Mater Chem B
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália