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Epidemiological characteristics and transmissibility of shigellosis in Hubei Province, China, 2005 - 2017.
Chen, Qi; Rui, Jia; Hu, Qingqing; Peng, Ying; Zhang, Hao; Zhao, Zeyu; Tong, Yeqing; Wu, Yang; Su, Yanhua; Zhao, Benhua; Guan, Xuhua; Chen, Tianmu.
Afiliação
  • Chen Q; Hubei Provincial Center for Disease Control and Prevention, NO.6 Zhuodaoquan North Road, Hongshan District, Wuhan City, Hubei Province, People's Republic of China.
  • Rui J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, People's Republic of China.
  • Hu Q; Division of Public Health, School of Medicine, University of Utah, 201 Presidents Circle, Salt Lake City, UT, 84112, USA.
  • Peng Y; Wuhan Center for Disease Control and Prevention, Wuhan City, Hubei Province, People's Republic of China.
  • Zhang H; Yichang Center for Disease Control and Prevention, Yichang City, Hubei Province, People's Republic of China.
  • Zhao Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, People's Republic of China.
  • Tong Y; Hubei Provincial Center for Disease Control and Prevention, NO.6 Zhuodaoquan North Road, Hongshan District, Wuhan City, Hubei Province, People's Republic of China.
  • Wu Y; Hubei Provincial Center for Disease Control and Prevention, NO.6 Zhuodaoquan North Road, Hongshan District, Wuhan City, Hubei Province, People's Republic of China.
  • Su Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, People's Republic of China.
  • Zhao B; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, People's Republic of China.
  • Guan X; Hubei Provincial Center for Disease Control and Prevention, NO.6 Zhuodaoquan North Road, Hongshan District, Wuhan City, Hubei Province, People's Republic of China. guanxh9999@163.com.
  • Chen T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, People's Republic of China. 13698665@qq.com.
BMC Infect Dis ; 20(1): 272, 2020 Apr 07.
Article em En | MEDLINE | ID: mdl-32264846
BACKGROUND: Shigellosis is one of the main diarrhea diseases in developing countries. However, the transmissibility of shigellosis remains unclear. METHODS: We used the dataset of shigellosis cases reported between January 2005 and December 2017, from Hubei Province, China. A mathematical model was developed based on the natural history and the transmission mechanism of the disease. By fitting the data using the model, transmission relative rate from person to person (b) and from reservoir to person (bw), and the effective reproduction number (Reff) were estimated. To simulate the contribution of b and bw during the transmission, we performed a "knock-out" simulation in four scenarios: A) b = 0 and bw = 0; B) b = 0; C) bw = 0; D) control (no intervention). RESULTS: A total of 130,770 shigellosis cases were reported in Hubei province, among which 13 cases were dead. The median annual incidence was 19.96 per 100,000 persons (range: 5.99 per 100,000 persons - 29.47 per 100,000 persons) with a decreased trend (trend χ2 = 25,470.27, P < 0.001). The mean values of b and bw were 0.0898 (95% confidence interval [CI]: 0.0851-0.0946) and 1.1264 × 10- 9 (95% CI: 4.1123 × 10- 10-1.8416 × 10- 9), respectively. The "knock-out" simulation showed that the number of cases simulated by scenario A was almost the same as scenario B, and scenario C was almost the same as scenario D. The mean value of Reff of shigellosis was 1.19 (95% CI: 1.13-1.25) and decreased slightly with a Linear model until it decreased to an epidemic threshold of 0.99 (95% CI: 0.65-1.34) in 2029. CONCLUSIONS: The incidence of shigellosis is still in high level. The transmissibility of the disease is low in Hubei Province. The transmission would be interrupted in the year of 2029.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_diarrhea / 3_neglected_diseases / 3_zoonosis Assunto principal: Shigella / Disenteria Bacilar / Epidemias Tipo de estudo: Incidence_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_diarrhea / 3_neglected_diseases / 3_zoonosis Assunto principal: Shigella / Disenteria Bacilar / Epidemias Tipo de estudo: Incidence_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article
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