Performance and toxicity of different absorption enhancers used in the preparation of Poloxamer thermosensitive in situ gels for ketamine nasal administration.

Xia, Yunjie; Li, Long; Huang, Xiaowu; Wang, Zengming; Zhang, Hui; Gao, Jing; Du, Yimeng; Chen, Wen; Zheng, Aiping

Xia, Yunjie; Li, Long; Huang, Xiaowu; Wang, Zengming; Zhang, Hui; Gao, Jing; Du, Yimeng; Chen, Wen; Zheng, Aiping.

Afiliação

Xia Y; Shihezi University, Shihezi, China.
Li L; State Key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing, China.
Huang X; The Fourth Military Medical University, Xi'an, China.
Wang Z; Pharmaceutical Department of Chinese, PLA General Hospital, Beijing, China.
Zhang H; State Key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing, China.
Gao J; State Key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing, China.
Du Y; State Key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing, China.
Chen W; State Key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing, China.
Zheng A; Shihezi University, Shihezi, China.

Drug Dev Ind Pharm ; 46(5): 697-705, 2020 May.

Article em En | MEDLINE | ID: mdl-32293206

Assuntos

Portadores de Fármacos/toxicidade; Ketamina/toxicidade; Absorção Nasal/efeitos dos fármacos; Mucosa Nasal/efeitos dos fármacos; Poloxâmero/toxicidade; Administração Intranasal/métodos; Analgésicos/síntese química; Analgésicos/metabolismo; Analgésicos/toxicidade; Animais; Anuros; Portadores de Fármacos/síntese química; Portadores de Fármacos/metabolismo; Feminino; Géis; Ketamina/síntese química; Ketamina/metabolismo; Masculino; Absorção Nasal/fisiologia; Mucosa Nasal/metabolismo; Técnicas de Cultura de Órgãos; Poloxâmero/síntese química; Poloxâmero/metabolismo; Ratos; Ratos Sprague-Dawley; Temperatura

Palavras-chave

Ketamine; absorption accelerator; ciliotoxicity; in situ gel; nasal mucosal toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Poloxâmero / Absorção Nasal / Ketamina / Mucosa Nasal Limite: Animals Idioma: En Revista: Drug Dev Ind Pharm Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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